期刊
CELLULAR MICROBIOLOGY
卷 11, 期 11, 页码 1571-1578出版社
WILEY
DOI: 10.1111/j.1462-5822.2009.01364.x
关键词
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资金
- National Institutes of Health
- Burroughs Wellcome Trust Fund Program
- Pathogenesis of Infectious Diseases
- American Heart Association Predoctoral Fellowship
P>Chlamydia sp. are responsible for a wide range of diseases of significant clinical and public health importance. In this review, we highlight how recent cellular and functional genomic approaches have significantly increased our knowledge of the pathogenic mechanisms used by these genetically intractable bacteria. As the extensive repertoire of chlamydial proteins that are translocated into the mammalian host is identified and characterized, a molecular understanding of how Chlamydiae co-opt host cellular functions and block innate immune pathways is beginning to emerge.
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