期刊
NATURE REVIEWS DRUG DISCOVERY
卷 1, 期 3, 页码 177-186出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd744
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The creation of efficient methods for manufacturing biotechnology drugs - many of which influence fundamental but complex cell behaviours, such as proliferation, migration and differentiation - is creating new opportunities for tissue repair. Many agents are potent and multifunctional; that is, they produce different effects within different tissues. Therefore, control of tissue concentration and spatial localization of delivery is essential for safety and effectiveness. Synthetic systems that can control agent delivery are particularly promising as materials for enhancing tissue regeneration. This review discusses the state of the art in controlled-release and microfluidic drug delivery technologies, and outlines their potential applications for tissue engineering.
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