期刊
BIOLOGICAL CHEMISTRY
卷 383, 期 3-4, 页码 547-552出版社
WALTER DE GRUYTER GMBH
DOI: 10.1515/BC.2002.055
关键词
antioxidant; atherosclerosis; LDL oxidation; lipid-protein adduct; nitric oxide; oxidative stress; peroxynitrite
Nitric oxide ((NO)-N-.) is a free radical species that diffuses and concentrates in the hydrophobic core of low-density lipoprotein (LDL) to serve as a potent inhibitor of lipid oxidation processes. Peroxynitrite (PN), the product of the diffusion-limited reaction between (NO)-N-. and superoxide (O-2(.-)), represents a relevant mediator of oxidative modifications in LDL. The focus of this review is the analysis of interactions between (NO)-N-. and PN and its secondary reactions with oxygen radicals on LDL oxidation, which are relevant in the development of the early steps as well as progression of atherosclerosis. We propose that the balance between rates of PN and (NO)-N-. production, which greatly depends on oxidative stress processes within the vascular wall, will critically determine the final extent of oxidative LDL modifications leading or not to scavenger receptor-mediated LDL uptake and foam cell formation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据