期刊
CELLULAR IMMUNOLOGY
卷 284, 期 1-2, 页码 75-83出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2013.07.008
关键词
AIF-1; Inflammation; Proliferation; Migration; Disease processes
资金
- Fundamental Research Funds for the Central Universities, Southwest University for Nationalities [13NZYBS11]
- National Science Foundation of China [81172511]
Allograft Inflammatory Factor-1 (AIF-1) is a 17 kDa cytoplasmic, calcium-binding, inflammation-responsive scaffold protein that is mainly expressed in immunocytes. AIF-1 influences the immune system at several key points and thus modulates inflammatory diseases. AIF-1 boosts the expression of inflammatory mediators such as cytokines, chemokines, inducible nitric oxide synthase (iNOS) and promotes inflammatory cell proliferation and migration. Here we provide an overview of the different pathological processes regulated by AIF-1 mainly including allograft rejection, autoimmune diseases, central nervous system (CNS) injury, vasculopathy and cancer et al. (C) 2013 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据