期刊
CELLULAR IMMUNOLOGY
卷 280, 期 1, 页码 22-35出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2012.11.009
关键词
Cathelicidin; Antimicrobial peptide; LL-37; Innate immunity
资金
- Agency for Innovation by Science and Technology (IWT)
Cathelicidins are a group of antimicrobial peptides. Since their discovery, it has become clear that they are an exceptional class of peptides, with some members having pleiotropic effects. Not only do they possess an antibacterial, antifungal and antiviral function, they also show a chemotactic and immunostimulatory/-modulatory effect. Moreover, they are capable of inducing wound healing, angiogenesis and modulating apoptosis. Recent insights even indicate for a role of these peptides in cancer. This review provides a comprehensive summary of the most recent and relevant insights concerning the human cathelicidin LL-37. (C) 2012 Elsevier Inc. All rights reserved.
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