期刊
CELLULAR IMMUNOLOGY
卷 277, 期 1-2, 页码 14-21出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2012.06.005
关键词
Chitin oligosaccharides; Microglia; Lipopolysaccharide; Nuclear factor-kappa B; Cyclooxygenase-2
资金
- Marine Bioprocess Research Center of the Marine Bio 21 Project
- Ministry of Land, Transport and Maritime, Republic of Korea
Chitin oligosaccharides (NA-COS) of two different molecular weight ranges (below 1 and 1-3 kDa) were examined for their capabilities against lipopolysaccharide-induced inflammatory responses in BV-2 murine It was found that NA-COS reduced the level of nitric oxide (NO) and prostaglandin E-2 (PGE(2)) production by suppressing the expression of NO synthase (iNOS) and cyclooxygenase (COX)-2 without significant cytotoxicity. Furthermore, the inhibitory effects of NA-COS on generation of interleukin (IL)-1 beta, IL-6, and tumor necrosis factor (TNF)-alpha were determined. Notably, NA-COS exerted anti-inflammatory activities via blocking degradation of inhibitor of kappaB-alpha (I kappa B-alpha), translocation of nuclear factor (NF)-kappa B, and phosphorylation of mitogen-activated protein kinases (MAPKs) in a dose-dependent manner. These findings provide mechanistic insights into the anti-inflammatory and neuroprotective actions of NA-COS in BV-2 microglia. (C) 2012 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据