期刊
CELLULAR IMMUNOLOGY
卷 274, 期 1-2, 页码 89-97出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2012.01.007
关键词
Tuberculosis; CD19(+)CD1d(+)CD5(+) B cell; Th17 cell
资金
- Eleven-Fifth Mega-Scientific Project on prevention and treatment of AIDS, viral hepatitis and other infectious diseases [2008ZX10003-005]
- Natural Science Foundation of China [81172732, 30872258]
Although the importance of B cells in the host immune response upon Mycobacterium tuberculosis infection has been recognized, a conclusive role for B cells has yet to be determined. In the present study, we found that primary CD19(+) B cells isolated from patients with tuberculosis significantly inhibited Th17, but not Th1, cell activation. Moreover, the suppressive activity was mediated by a CD19(+)CD1d(+)CO5(+) B cell population. Notably, patients with tuberculosis were found to have significantly higher frequencies of CD19(+)CD1d(+)CD5(+) B cells with stronger suppressive activity than such cells from healthy donors. Furthermore, the frequency of CD19(+)CD1d(+)CD5(+) B cells in peripheral blood was inversely correlated with that of Th17 cells in patients with tuberculosis. This finding that B cells negatively regulate Th17 responses provides a novel mechanism in the regulation of CD4(+) T cell responses aside from regulatory T cells during M. tuberculosis infection, which may impact the clinical outcome of tuberculosis. (C) 2012 Elsevier Inc. All rights reserved.
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