期刊
NEUROPSYCHOLOGIA
卷 40, 期 13, 页码 2257-2267出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0028-3932(02)00108-2
关键词
sensitivity to reinforcement; mesocorticolimbic dopaminergic system; striatofrontal loops
Orbitofrontal and cingulate striatofrontal loops and the mesolimbic dopaminergic system that modulates their function have been implicated in motivation and sensitivity to reinforcement in animals. Parkinson's disease (PD) provides a model to assess their implications in humans. The aims of the study were to investigate motivation and sensitivity to reinforcement in non-demented and -depressed PD patients and to evaluate the influence of dopaminergic therapy by comparing patients in on (with L-Dopa) and off' (without L-Dopa) states. Twenty-three PD patients were compared, in both the on and off' states, to 28 controls, using: (1) an Apathy Scale; (2) Stimulus-Reward Learning, Reversal, and Extinction tasks; and (3) a Gambling task. PD patients were found: (1) mildly apathetic; (2) impaired on Stimulus-Reward Learning and Reversal, but not on Extinction; and (3) able to progress in the Gambling task during the first, but not the second assessment. There was no significant correlation between these various deficits. L-Dopa treatment clearly improved motivation, but had more limited and contrasting effects on other variables, decreasing the number of omission errors in Reversal, but increasing the number of perseveration errors in Extinction. These results suggest: (1) an implication of striatofrontal loops in human motivation and explicit and implicit sensitivity to reinforcement; (2) a positive influence Of L-Dopa treatment on the subjective evaluation of motivation, but contrasting effects on reward sensitivity. (C) 2002 Elsevier Science Ltd. All rights reserved.
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