期刊
CELLULAR IMMUNOLOGY
卷 274, 期 1-2, 页码 12-18出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2012.02.012
关键词
Tolerogenic dendritic cell; Heart transplantation; Rejection; Regulatory T cell
资金
- National Natural Science Foundation of China [30671993]
- Fundamental Research Funds for the Central Universities [201130202020010]
- Ministry of Education
It is well known that adoptive transfer of donor-derived tolerogenic dendritic cells (DCs) helps to induce immune tolerance. RelB, one of NF-kappa B subunits, is a critical element involved in DC maturation. In the present study, our results showed tolerogenic DCs could be acquired via silencing RelB using small interfering RNA. Compared with imDCs, the tolerogenic DCs had more potent ability to inhibit mixed lymphocyte reaction (MLR) and down-regulate Th1 cytokines and prompt the production of Th2 cytokines. They both mediated immune tolerance via the increased of T cell apoptosis and generation of regulatory T cells. Administration of donor-derived tolerogenic DCs significantly prevented the allograft rejection and prolonged the survival time in a murine heart transplantation model. Our results demonstrate donor-derived, RelB-shRNA induced tolerogenic DCs can significantly induce immune tolerance in vitro and in vivo. (C) 2012 Elsevier Inc. All rights reserved.
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