期刊
ACTA OTO-LARYNGOLOGICA
卷 122, 期 1, 页码 61-66出版社
TAYLOR & FRANCIS AS
DOI: 10.1080/00016480252775751
关键词
nitric oxide; respiratory syncytial virus; upper respiratory infection
资金
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000084] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI019262] Funding Source: NIH RePORTER
- NCRR NIH HHS [5M01 RR00084] Funding Source: Medline
- NIAID NIH HHS [AI19262] Funding Source: Medline
Nitric oxide (NO) is a recognized mediator of inflammation in diseases affecting the lower respiratory tract, and has been implicated in the expression of viral upper respiratory tract infections. Here, exhaled nasal and oral NO concentrations and nitrite concentrations in nasal lavage fluids were measured, symptoms were scored and pulmonary function was evaluated before (Day 0) and after (Days 1-8) experimental exposure of 17 adult subjects to respiratory syncytial virus (RSV) type B. After exposure, RSV was recovered from 12 (70%) subjects by culture and/or specific antigen detection. Both subjects with and those without RSV recovery developed increased nasal and throat symptoms after RSV exposure, but none evidenced changes in the three measures of NO concentration. These results do not support the hypothesis of increased NO production during RSV infection and complement earlier studies that reported a lack of change in nasal NO concentration during experimental influenza and rhinovirus infections.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据