期刊
NEUROPSYCHOLOGIA
卷 40, 期 12, 页码 2116-2124出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0028-3932(02)00052-0
关键词
error-processing; error-related negativity; efference copy; dopamine; basal ganglia; frontal cortex
资金
- NIMH NIH HHS [MH11530] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [F31MH011530] Funding Source: NIH RePORTER
Several lines of evidence indicate that people with Parkinson's disease are impaired at detecting their own motor errors. In the present study, we use a component of the event-related brain potential called the error-retated negativity (ERN) to ask whether a high-level, generic error-processing system is compromised in Parkinson's disease. We recorded the electroencephalogram (EEG) from nine patients with mild to moderate Parkinson's disease and from nine normal control subjects while they performed a choice reaction time task. We found that the amplitude of the ERN was the same for both populations, indicating that the error-processing system associated with the ERN is not severely compromised in this Parkinson's disease population. These results are discussed in terms of disease progession. (C) 2002 Elsevier Science Ltd. All rights reserved.
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