期刊
CELLULAR IMMUNOLOGY
卷 263, 期 2, 页码 196-203出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2010.03.016
关键词
Murine paracoccidioidomycosis; Macrophages; Fungicidal activity; IL-10; TGF-beta; NO; H2O2
资金
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Brazil [00/04876-8]
Paracoccidioidomycosis is caused by the thermally dimorphic fungus Paracoccidioides brasiliensis (P brasiliensis). Most often, this mycosis runs as a chronic progressive course affecting preferentially the lungs. In vitro fungicidal activity against a high virulent strain of P brasiliensis by murine peritoneal macrophages preactivated with IFN-gamma or TNF-alpha is high and correlates with increased NO and H2O2 production. Within this context, the purpose of this work was to study the role of suppressor cytokines, such as IL-10 and TGF-beta, in this process. Incubation of either IFN-gamma or TNF-alpha with IL-10 inhibits fungicidal activity of these cells However, TGF-beta had no effect on fungicidal activity of IFN-gamma or TNF-alpha-activated macrophages. The suppression of fungicidal activity by IL-10 correlated with the inhibition of NO and H2O2 production supporting the involvement of these metabolites in P brasiliensis killing These results suggest that IL-10 production in vivo could represent an evasion mechanism of the fungus to avoid host immune response (C) 2010 Elsevier Inc All rights reserved.
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