Mesenchymal stromal cells use PGE2 to modulate activation and proliferation of lymphocyte subsets: Combined comparison of adipose tissue, Wharton's Jelly and bone marrow sources

Due to their immunomodulatory properties, adipose tissue (AT) and Wharton's Jelly (WJ) constitute valuable alternatives to BM as sources of MSCs for managing graft-versus-host disease To ensure the efficiency of AT- and WJ-MSCs implies the characterization of their immunomodulatory functions in comparison to those of BM In this study, we investigated the capacity of AT- and WJ-MSCs to modulate lymphocyte ieactions in response to different stimuli as well as the specificity of this immunomodulanon AT- and WJ-MSC displayed potent immunosuppressive effects on lymphocyte responses in a dose-dependent manner These effects included the prevention of lymphocyte activation as well as the suppression of T-cell proliferation regardless of the stimuli used to activate lymphocytes These effects were mediated through the expression of COX1/C0X2 enzymes and by the production of PGE2 CD4(+) and CD8(+) T-lymphocytes were equally targeted by MSCs demonstrating that the immunomodulation was not restricted to a specific T-cell subpopulation (C) 2010 Elsevier Inc All rights reserved