期刊
NATURE IMMUNOLOGY
卷 3, 期 1, 页码 27-32出版社
NATURE AMERICA INC
DOI: 10.1038/ni742
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资金
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R56AI017134, P01AI022295, R01AI017134, R01AI018785, R37AI017134, R37AI018785] Funding Source: NIH RePORTER
- NIAID NIH HHS [AI17134, AI18785, AI22295] Funding Source: Medline
T cells compete in the response to antigen in vivo and this competition may drive the affinity maturation of a secondary T cell response. Here we show that high-affinity T cells out-competed lower affinity T cells during a response to antigenic challenge in vivo. Although competition between T cells specific for different peptide-major histocompatibility complexes (MHC) occurred, it was less efficient than competition between T cells of the same peptide-MHC specificity. In addition, high-affinity T cells efficiently induced antigen loss from the surface of antigen-presenting cells. Thus T cells that responded to the same peptide-MHC competed with each other by lowering the amount of ligand with which the cells could react. As a result, the activation of high-affinity cells was favored. This provides a mechanism for the affinity maturation of a secondary T cell response.
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