期刊
CELLULAR IMMUNOLOGY
卷 261, 期 1, 页码 9-22出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2009.10.004
关键词
B-cells; Autoimmunity; Anti-dsDNA antibodies; BAFF; B-cell regulation; Tolerance; Anergy; Systemic lupus erythematosus (SLE)
资金
- NIH/NCRR/RCMI [5G12 RR03060-24]
- IGMS/SCORE [S06 GM 08168]
- City University of New York
- New York Chapter of the Arthritis Foundation
- NATIONAL CENTER FOR RESEARCH RESOURCES [G12RR003060] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [S06GM008168] Funding Source: NIH RePORTER
Overexpression of BAFF is believed to play an important role in systemic lupus erythematosus and elevated levels of serum BAFF have been found in lupus patients. Excess BAFF also leads to overproduction of anti-dsDNA antibodies and a lupus-like syndrome in mice. In the present study, we use mice transgenic for the R4A-C mu (IgM) heavy chain of an anti-dsDNA antibody, to study the effects of BAFF overexpression on anti-dsDNA B-cell regulation. We observe that overexpression of BAFF promotes anti-dsDNA B-cell maturation and secretion of antibody and enriches for transgenic anti-dsDNA B cells in the marginal zone and follicular splenic compartments. In addition, our data suggests that BAFF rescues a subset of anti-dsDNA B cells from a regulatory checkpoint in the transitional stage of development. (C) 2009 Elsevier Inc. All rights reserved.
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