期刊
CELLULAR IMMUNOLOGY
卷 254, 期 2, 页码 94-104出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2008.07.002
关键词
Mycobacterium; Macrophage; Dendritic cell; MHC; Antigen presentation
资金
- NATIONAL CANCER INSTITUTE [P30CA043703] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL055967] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI035726, R01AI034343, R01AI027243, R01AI069085] Funding Source: NIH RePORTER
- NCI NIH HHS [P30 CA43703, P30 CA043703] Funding Source: Medline
- NHLBI NIH HHS [HL55967, R01 HL055967] Funding Source: Medline
- NIAID NIH HHS [R01 AI069085-01A1, R01 AI035726-12, R01 AI069085-03, AI035726, AI034343, R01 AI034343-12, R01 AI035726-13, R01 AI035726-14, R01 AI035726-11A2, R01 AI069085-02, AI069085, R01 AI034343-13, R01 AI035726-10, AI27243, R01 AI034343-14A1, R01 AI035726, R01 AI069085, R01 AI034343, R01 AI027243] Funding Source: Medline
Mycobacterium tuberculosis and M. bovis BCG infect APCs. In vitro, mycobacteria inhibit IFN-gamma-induced MHC-II expression by macrophages, but the effects of mycobacteria on lung APCs in vivo remain unclear. To assess MHC-II expression on APCs infected in vivo, mice were aerosol-infected with GFP-expressing BCG. At 28 cl, similar to 1% of lung APCs were GFP+ by flow cytometry and CFU data. Most GFP+ cells were CD11b(high)/CD11c(neg-mid) lung macrophages (58-68%) or CD11b(high)/CD11c(high) DCs (28-31%). Lung APC MHC-II expression was higher in infected mice than naive mice. Within infected lungs, however, MHC-II expression was lower in GFP+ cells than GFP- cells for both macrophages and DCs. MHC-II expression was also inhibited on purified lung macrophages and DCs that were infected with BCG in vitro. Thus, lung APCs that harbor mycobacteria in vivo have decreased MHC-II expression relative to uninfected APCs from the same lung, possibly contributing to evasion of T cell responses. (c) 2008 Elsevier Inc. All right reserved.
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