期刊
CELLULAR IMMUNOLOGY
卷 254, 期 2, 页码 142-148出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2008.08.005
关键词
Filopodia; Communication; AIDS; Inflammation; Infectivity; HIV
资金
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [P30AI051519] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH075679, R01MH070297, K01MH076679] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [T32NS007098] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [F32DA024965] Funding Source: NIH RePORTER
Cell to cell communication is essential for the organization/coordination of multicellular systems and cellular development. Cellular communication is mediated by soluble factors, including growth factors, neurotransmitters, cytokines/chemokines, gap junctions, and the recently described tunneling nanotubes (TNT). TNT are long cytoplasmatic bridges that enable long range directed communication between cells. The proposed function for TNT is the cell-to-cell transfer of large cellular structures such as vesicles and organelles. We demonstrate that HIV-infection of human macrophages results in an increased number of TNT, and show HIV particles within these structures. We propose that HIV highjacks TNT communication to spread HIV through an intercellular route between communicated cells, contributing to the pathogenesis of AIDS. (c) 2008 Elsevier Inc. All rights reserved.
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