期刊
CELLULAR IMMUNOLOGY
卷 259, 期 1, 页码 1-4出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2009.06.002
关键词
CpG; Mycobacterium tuberculosis; Phospholipase D; Phagolysosome
资金
- Italian Ministry of University
CpG oligodeoxynucleotides have been previously shown to enhance anti mycobacterial response in human monocytes/macrophages. The present study reports evidences showing the capability of CpG oligodeoxynucleotides to induce (i) host phospholipase D (PLD) activation, (ii) PLD dependent reactive oxygen intermediate production, (iii) PLD dependent phagolysosome maturation and (iv) PLD dependent intracellular mycobacterial killing in type II alveolar epithelial cells. These are the first evidences showing that alveolar epithelial cells may represent efficient effecter cells during primary innate antimycobacterial immune response. (C) 2009 Elsevier Inc. All rights reserved.
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