期刊
CELLULAR IMMUNOLOGY
卷 252, 期 1-2, 页码 57-67出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2007.09.007
关键词
estrogen; testosterone; macrophage; neutrophil; T cell; injury; burn; trauma-hemorrhage; cytokines; immunity; inflammation
资金
- National Institutes of Health [AA12034, AG18859, T32 AA 13527]
- Ralph and Marion C. Falk Foundation
- Illinois Excellence in Academic Medicine Grant
- NATIONAL INSTITUTE ON AGING [R01AG018859] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [F31AA017027, R01AA012034, T32AA013527] Funding Source: NIH RePORTER
Cell-mediated immunity is extremely important for resolution of infection and for proper healing from injury. However, the cellular immune response is dysregulated following injuries such as burn and hemorrhage. Sex hormones are known to regulate immunity, and a well-documented dichotomy exists in the immune response to injury between the sexes. This disparity is caused by differences in immune cell activation, infiltration, and cytokine production during and after injury. Estrogen and testosterone can positively or negatively regulate the cellular immune response either by aiding in resolution or by compounding the morbidity and mortality. It is apparent that the hormonal dysregulation is dependent not only on the type of injury sustained but also the amount of circulating hormones. Therefore, it may be possible to design sex-specific therapies to improve immunological function and patient outcome. (C) 2008 Elsevier Inc. All rights reserved.
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