期刊
ANALYTICAL LETTERS
卷 35, 期 7, 页码 1163-1170出版社
MARCEL DEKKER INC
DOI: 10.1081/AL-120005970
关键词
spectrophotometry; amitriptyline; desipramine; ion-association compounds
Amitriptyline and desipramine hydrochlorides react with niobium (V) thiocyanate complex forming yellow ion-association compounds. These compounds are insoluble in water, but fairly soluble in organic solvents. The formation and extraction conditions of the compounds have been established, and a new spectrophotometric method has been developed for the determination of amitriptyline and desipramine in the concentration range of 1-12 mug/mL and 1-6 mug/mL, respectively.
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