期刊
CELLULAR AND MOLECULAR NEUROBIOLOGY
卷 34, 期 5, 页码 651-657出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10571-014-0039-8
关键词
Mangiferin; Lipopolysaccharide; Brain; Interleukin-6; Cystathionine beta-synthase
资金
- National Natural Science Foundation of China [31100762, 81371300]
- Education Departmental Natural Science Research Funds of Jiangsu Provincial Higher School of China [11KJB310013, 13KJB310021]
- Key Laboratory of Brain Disease Bioinformation of Jiangsu Province [Jsbl1102]
- Foundation of President of Xuzhou Medical College [2012KJZ06, 2011KJ11]
- Qing Lan Project of Jiangsu Province
Mangiferin has been extensively applied in different fields due to its anti-inflammatory properties. However, the precise mechanism used by mangiferin on lipopolysaccharide (LPS)-induced inflammation has not been elucidated. Here, we discuss the potential mechanism of mangiferin during a LPS-induced brain injury. Brain injury was induced in ICR mice via intraperitoneal LPS injection (5 mg/kg). Open- and closed-field tests were used to detect the behaviors of mice, while immunoblotting was performed to measure the expression of interleukin-6 (IL-6) and cystathionine-b-synthase (CBS) in the hippocampus after mangiferin was orally administered (p.o.). Mangiferin relieved LPS-induced sickness 6 and 24 h after LPS injection; in addition, this compound suppressed LPS-induced IL-6 production after 24 h of LPS induction as well as the downregulation of LPS-induced CBS expression after 6 and 24 h of LPS treatment in the hippocampus. Therefore, mangiferin attenuated sickness behavior by regulating the expression of IL-6 and CBS.
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