期刊
CELLULAR AND MOLECULAR NEUROBIOLOGY
卷 33, 期 7, 页码 867-873出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10571-013-9961-4
关键词
Bobby sox; Nuclear factor one X; Neural progenitor cell; Transcription factor
资金
- National Health and Medical Research Council (NHMRC) [1022308, 1003462]
- NYSTEM [C026429]
- NIH [HL 080624]
- Australian Research Council
The transcription factor nuclear factor one X (NFIX) plays a central role during the development of the neocortex and hippocampus, through the activation of astrocyte-specific gene expression and the repression of progenitor-specific pathways. However, our understanding of transcriptional targets of NFIX during cortical development remains limited. Here, we identify the transcription factor Bobby sox (Bbx) as a target for NFI-mediated transcriptional control. BBX is expressed within ventricular zone progenitor cells within the developing neocortex and hippocampus, and its expression is upregulated in Nfix (-/-) mice. Moreover, we reveal that NFIX can repress Bbx promoter-driven expression. Collectively, these data suggest that Bbx is a downstream target of NFIX during development of the forebrain.
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