期刊
CELLULAR AND MOLECULAR NEUROBIOLOGY
卷 32, 期 3, 页码 467-475出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10571-011-9779-x
关键词
Streptzotocin(STZ); Diabetic retinopathy; Gene therapy; Adeno-associated virus (AAV); Brain-derived neurotrophic factor (BDNF)
Adeno-associated virus vector plasmid carrying the expression cassette of brain-derived neurotrophic factor (BDNF), pAAV-BDNF, was constructed and packaged into recombinant adeno-associated virus (rAAV-BDNF). The rAAV-BDNF was intravitreally injected into streptzotocin (STZ)-induced diabetic Sprague-Dawley (SD) Rats. Data showed that over-expression of BDNF could increase alive retinal ganglion cell (RGC) number and improve its function in streptzotocin(STZ)-induced diabetic rats, which might be a new method to treat diabetic neuropathy and retinopathy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据