期刊
CELLULAR AND MOLECULAR NEUROBIOLOGY
卷 31, 期 6, 页码 939-948出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10571-011-9691-4
关键词
Alzheimer's disease; Synapse degeneration; A beta oligomers; mGluR5; Fragile X syndrome; Insulin dysfunction
资金
- NIA NIH HHS [R01 AG029460, R01 AG029460-03] Funding Source: Medline
A beta oligomers cause a collection of molecular events associated with memory loss in Alzheimer's disease, centering on disrupting the maintenance of synapse structure and function. In this brief review of the synaptotoxic effects of A beta oligomers, we focus on the neuronal properties governing oligomer targeting and toxicity-especially with respect to binding sites and mechanisms of binding. We also discuss ways in which mechanistic insights from other diseases offer clues in the pursuit of the molecular basis of Alzheimer's disease.
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