期刊
MOLECULAR PSYCHIATRY
卷 7, 期 10, 页码 1054-1057出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.mp.4001105
关键词
obsessive-compulsive disorder; 5HT(2A) polymorphism; association study; child and adolescent psychiatry
Positive association between obsessive compulsive disorder (OCD) and the A-allele of the 5-HT2A-receptor promoter pollymorphism -1438G/A has recently been reported in adults. We performed an association analysis of this polymorphism in 55 children and adolescents with OCD and in 223 controls consisting of unrelated students. We detected statistically significant differences in genotype (P < 0.05) and allele frequencies (P < 0.05) between individuals with OCD and controls. In this, to our knowledge, first association study based on children and adolescents with OCD, we confirm an association of the A-allele of the 5-HT2A receptor gene with OCD.
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