期刊
HORMONE AND METABOLIC RESEARCH
卷 34, 期 3, 页码 144-149出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2002-23198
关键词
aging; cardiovascular disease; coronary heart disease; insulin-like growth factor binding protein-1 insulin-like growth factor-I
资金
- NATIONAL INSTITUTE ON AGING [R01AG008762] Funding Source: NIH RePORTER
- NIA NIH HHS [AGO 8762] Funding Source: Medline
Insulin-like growth factor binding protein-1 (IGFBP-1) has been implicated in the development of cardiovascular disease, but it is not known whether IGFBP-1 is related to cardiovascular mortality. We examined the relation of circulating IGFBP-1 to death from coronary heart disease, cardiovascular disease, and all causes in a cohort Study consisting of 622 men aged 65 - 84 years, at baseline in 1984. Fasting serum IGFBP-1 and other risk factors were measured in 1984 and 1989. Cardiovascular events for those who died between 1984 and 1995 were analyzed, and cardiovascular diagnoses were coded centrally according to standardized procedures. Of the 622 men, 358 died between 1984 and 1995; 160 deaths were due to cardiovascular causes, 113 of which were coronary deaths. High fasting serum IGFBP-1 concentration (> 75 percentile) in 1984 was associated with increased five-year total mortality (OR 2.05, 95% CI 1.41 - 2.99; p<0.0002), cardiovascular mortality (OR 2.20, 95% Cl 1.37-3.50; p < 0.0009) and coronary heart disease mortality (OR 2.29, 95% Cl 1.35 - 3.88; p < 0.002). After adjustment for age, high serum IGFBP-1 concentrations still carried an increased risk of total mortality due to (OR 1.73, 95% Cl 1.16 - 2.59; p < 0.007), cardiovascular (OR 1.91 95% Cl 1.18 - 3.09; p < 0.008) and coronary heart disease (OR 2.02. 95% Cl 1.18 - 3.47, p < 0.01). In conclusion, high fasting serum IGFBP-1 is related to increased five-year total and cardiovascular mortality in elderly men.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据