期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 71, 期 20, 页码 4007-4026出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-014-1675-3
关键词
Mouse models; Glioma; Medulloblastoma; Cell of origin; Neural stem cells
资金
- Fondation ARC pour la Recherche sur le Cancer
- Ligue Nationale Contre le Cancer
- Institut National de la Sante et de la Recherche Medicale (INSERM)
- European Union
- program Investissements d'avenir [ANR-10-IAIHU-06]
Although our knowledge of the biology of brain tumors has increased tremendously over the past decade, progress in treatment of these deadly diseases remains modest. Developing in vivo models that faithfully mirror human diseases is essential for the validation of new therapeutic approaches. Genetically engineered mouse models (GEMMs) provide elaborate temporally and genetically controlled systems to investigate the cellular origins of brain tumors and gene function in tumorigenesis. Furthermore, they can prove to be valuable tools for testing targeted therapies. In this review, we discuss GEMMs of brain tumors, focusing on gliomas and medulloblastomas. We describe how they provide critical insights into the molecular and cellular events involved in the initiation and maintenance of brain tumors, and illustrate their use in preclinical drug testing.
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