期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 22, 期 3, 页码 262-270出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00004647-200203000-00003
关键词
brain; ischemia; MRI; T-2 relaxation; luxury perfusion; blood oxygenation level-dependent contrast
The balance between oxygen consumption and delivery in the rat brain after exposure to transient ischemia was quantitatively studied with single-spin echo T-2-BOLD (blood oxygenation level-dependent) magnetic resonance imaging at 4.7 T. The rats were exposed to graded common carotid artery occlusions using a modification of the four-vessel model of Pulsinelli. T-2 diffusion, and cerebral blood volume were quantified with magnetic resonance imaging, and CBF was measured with the hydrogen clearance method. A transient common carotid artery occlusion below the CBF value of approximately 20 mL(.)100 g(-1.)min(-1) was needed to yield a T-2 increase of 4.6 +/- 1.2 milliseconds (approximately 9% of cerebral T-2) and 6.8 +/- 1.7 milliseconds (approximately 13% of cerebral T.) after 7 and 15 minutes of ischemia, respectively. Increases in CBF of 103 +/- 75% and in cerebral blood volume of 29 +/- 20% were detected in the reperfusion phase. These hemodynamic changes alone could account for only approximately one third of the T-2 increase in luxury perfusion, suggesting that a substantial increase in blood oxygen saturation (resulting from reduced oxygen extraction by the brain) is needed to explain the magnetic resonance imaging observation.
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