期刊
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
卷 32, 期 -, 页码 50-54出版社
WILEY
DOI: 10.1046/j.1365-2362.2002.0320s1050.x
关键词
iron; nontransferrin-bound iron
Nontransferrin-bound iron is now recognized to exist by many workers. It is present in the serum of patients suffering from a wide range of disease states and may be induced by certain therapeutic treatments. The chemical nature of this iron pool is unknown but almost certainly it is a multicomponent pool including a considerable proportion of protein-bound iron. Methods are required to separate and quantify these different components. The biological properties of the individual isoforms need to be established; it is possible that some forms are relatively nontoxic, while others are highly toxic. This paper reviews what is known about the nature of nontransferrin-bound iron and describes the methods currently available to quantify this important serum component.
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