期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 71, 期 23, 页码 4507-4517出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-014-1718-9
关键词
Genome instability; Replication fork arrest; Replication checkpoint; Werner syndrome protein; Common fragile sites
资金
- Association for International Cancer Research
- Associazione Italiana per la Ricerca sul Cancro (AIRC)
The acquisition of genomic instability is a triggering factor in cancer development, and common fragile sites (CFS) are the preferential target of chromosomal instability under conditions of replicative stress in the human genome. Although the mechanisms leading to CFS expression and the cellular factors required to suppress CFS instability remain largely undefined, it is clear that DNA becomes more susceptible to breakage when replication is impaired. The models proposed so far to explain how CFS instability arises imply that replication fork progression along these regions is perturbed due to intrinsic features of fragile sites and events that directly affect DNA replication. The observation that proteins implicated in the safe recovery of stalled forks or in engaging recombination at collapsed forks increase CFS expression when downregulated or mutated suggests that the stabilization and recovery of perturbed replication forks are crucial to guarantee CFS integrity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据