期刊
IMMUNITY
卷 16, 期 3, 页码 355-364出版社
CELL PRESS
DOI: 10.1016/S1074-7613(02)00284-4
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资金
- NIDDK NIH HHS [DK 46763, DK 54451] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R29DK054451, R01DK054451, P01DK046763] Funding Source: NIH RePORTER
The origin and specificity of alphabeta TCR+ T cells that express CD8alphaalpha have been controversial issues. Here we provide direct evidence that precursors of functional CD8alphaalpha T cells are positively selected in the thymus in the presence of agonist self-peptides. Like conventional positive selection, this agonist selection process requires functional TCR alpha-CPM, whereas it is independent of CD8beta expression. Furthermore, CD8alphaalpha expression on mature, agonist-selected T cells does not imply selection by MHC class I, and CD8alphaalpha(+) T cells can be either class I or class II restricted. Our data define a distinct agonist-dependent, positive selection process in the thymus, and they suggest a function for CD8alphaalpha distinct from the conventional TOR coreceptor function of CD8alphabeta or CD4.
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