期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 70, 期 18, 页码 3375-3390出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-012-1243-7
关键词
Ets1; B lymphocyte; Transcription factor; Gene regulation
资金
- National Institutes of Health [AI085127, AI099422]
- Alliance for Lupus Research
The Ets1 transcription factor is a member of the Ets gene family and is highly conserved throughout evolution. Ets1 is known to regulate a number of important biological processes in normal cells and in tumors. In particular, Ets1 has been associated with regulation of immune cell function and with an aggressive behavior in tumors that express it at high levels. Here we review and summarize the general features of Ets1 and describe its roles in immunity and autoimmunity, with a focus on its roles in B lymphocytes. We also review evidence that suggests that Ets1 may play a role in malignant transformation of hematopoietic malignancies including B cell malignancies.
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