期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 70, 期 10, 页码 1675-1684出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-013-1277-5
关键词
Neurovascular; Neural tube; Retina; Hindbrain; VEGF; Semaphorins; Neuropilin; GPCR124; TGF beta
资金
- NIH [R01 HL43174, HL86465]
- Wellcome Trust [095623/Z/11/Z]
- Wellcome Trust [095623/Z/11/Z] Funding Source: Wellcome Trust
The developing central nervous system (CNS) is vascularized via ingression of blood vessels from the outside as the neural tissue expands. This angiogenic process occurs without perturbing CNS architecture due to exquisite cross-talk between the neural compartment and invading blood vessels. Subsequently, this intimate relationship also promotes the formation of the neurovascular unit that underlies the blood-brain barrier and regulates blood flow to match brain activity. This review provides a historical perspective on research into CNS blood vessel growth and patterning, discusses current models used to study CNS angiogenesis, and provides an overview of the cellular and molecular mechanisms that promote blood vessel growth and maturation. Finally, we highlight the significance of these mechanisms for two different types of neurovascular CNS disease.
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