期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 70, 期 10, 页码 1753-1761出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-013-1282-8
关键词
Vascular endothelial growth factor; Stroke; Ischemia; Neuroprotection; Neurogenesis; Angiogenesis
资金
- National Institutes of Health [R01 NS44921]
Vascular endothelial growth factors (VEGFs) have been shown to participate in atherosclerosis, arteriogenesis, cerebral edema, neuroprotection, neurogenesis, angiogenesis, postischemic brain and vessel repair, and the effects of transplanted stem cells in experimental stroke. Most of these actions involve VEGF-A and the VEGFR-2 receptor, but VEGF-B, placental growth factor, and VEGFR-1 have been implicated in some cases as well. VEGF signaling pathways represent important potential targets for the acute and chronic treatment of stroke.
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