期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 70, 期 19, 页码 3481-3492出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-012-1251-7
关键词
Collective cell migration; Epithelium-to-mesenchyme transition; Contact-inhibition of locomotion; Chemotaxis; Mechanosensing; Mesoderm; Neural crest cells; Cancer
资金
- MRC
- BBSRC
- Wellcome Trust
- Wellcome Trust Value in People award
- MRC [MR/J000655/1] Funding Source: UKRI
- Medical Research Council [MR/J000655/1] Funding Source: researchfish
Directional cell migration is required for proper embryogenesis, immunity, and healing, and its underpinning regulatory mechanisms are often hijacked during diseases such as chronic inflammations and cancer metastasis. Studies on migratory epithelial tissues have revealed that cells can move as a collective group with shared responsibilities. First thought to be restricted to proper epithelial cell types able to maintain stable cell-cell junctions, the field of collective cell migration is now widening to include cooperative behavior of mesenchymal cells. In this review, we give an overview of the mechanisms driving collective cell migration in epithelial tissues and discuss how mesenchymal cells can cooperate to behave as a collective in the absence of bona fide cell-cell adhesions.
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