期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 7, 期 -, 页码 D593-D607出版社
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/pletnik
关键词
animal model; autism; Borna; brain; development; environment; rat; review
资金
- NIMH NIH HHS [R01 MH 48948-08A1] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH048948] Funding Source: NIH RePORTER
Autism spectrum disorders (ASD) have been the focus of a great deal of research and clinical speculation. This intense interest relates to both the perplexing pathogenesis and devastating consequences of these disorders. One of the obstacles to understanding the pathogenesis of autism and its efficient treatment has been the paucity of animal models that could be used for hypotheses-driven mechanistic studies of abnormal brain and behavior development and for the pre-clinical testing novel pharmacological treatments. The present review provides a detailed analysis of a new animal model of ASD. This model utilizes neonatal Borna disease virus (BDV) infection of the rat brain as a unique experimental teratogen to study the pathogenesis of neurodevelopmental damage. For more than a decade, studies of the BDV animal model have yielded much insight into the pathogenic processes of abnormal brain development and resulting autistic-like behavioral abnormalities in rats. The most recent experiments demonstrate the utility of the BDV model for studying the pathophysiological mechanisms of the gene-environment interaction that determines differential disease outcomes and variability in responses to treatments.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据