期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 70, 期 10, 页码 1779-1792出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-013-1312-6
关键词
Angiogenesis; Neurogenesis; Neurovascular interactions; Notch; VEGFs; VEGFRs
资金
- Yale University School of Medicine
- NIH [RO1HL111504-02]
- ANR
- Academy of Finland
Notch cell interaction mechanism governs cell fate decisions in many different cell contexts throughout the lifetime of all Metazoan species. It links the fate of one cell to that of its neighbors through cell-to-cell contacts, and binding of Notch receptors expressed on one cell to their membrane bound ligands on an adjacent cell. Environmental cues, such as growth factors and extracellular matrix molecules, superimpose a dynamic regulation on this canonical Notch signaling pathway. In this review, we will focus on Notch signaling in the vertebrate vascular and nervous systems and examine its role in angiogenesis, neurogenesis, and neurovascular interactions. We will also highlight the molecular relationships of the Notch pathway with vascular endothelial growth factors (VEGFs) and their high-affinity tyrosine kinase VEGF receptors, key regulators of both angiogenesis and neurogenesis.
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