期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 71, 期 3, 页码 365-378出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-013-1337-x
关键词
Thymic stromal lymphopoietin; CRLF2; IL7 receptor alpha; JAK1; JAK2; Leukemia
资金
- Israel Science Foundation
- Waxman Cancer Foundation
- Swiss Bridge Foundation
- William Lawrence & Blanche Hughes Foundation
- Children With Cancer UK
- Clinical Genetic Foundation
- Israel Cancer Research Foundation
Cancer is often caused by deregulation of normal developmental processes. Here, we review recent research on the aberrant activation of two hematopoietic cytokine receptors in acute lymphoid leukemias. Somatic events in the genes for thymic stromal lymphopoietin and Interleukin 7 receptors as well as in their downstream JAK kinases result in constitutive ligand-independent activation of survival and proliferation in B and T lymphoid precursors. Drugs targeting these receptors or the signaling pathways might provide effective therapies of these leukemias.
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