期刊
MICROBES AND INFECTION
卷 4, 期 3, 页码 351-359出版社
ELSEVIER
DOI: 10.1016/S1286-4579(02)01548-4
关键词
Slc11a1; Nramp1; natural immunity; macrophage; iron metabolism
Slc11a1 (solute carrier family 11 member 1) (formerly Nramp1) modulation of iron metabolism in macrophages plays an important role in the early phase of macrophage activation, and therefore host innate immunity. This review focuses on the role of Nramp1 in intramacrophage iron metabolism, with emphasis on the two prevailing mechanisms of Nramp1 modulation of iron metabolism in macrophages. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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