期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 70, 期 20, 页码 3893-3905出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-013-1302-8
关键词
Cilium; Cell cycle; G0/G1-S transition; Aurora-A; HEF1; Trichoplein
资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Japan Society for the Promotion of Science, Japan
- Ministry of Health, Labour and Welfare, Japan
- Uehara Memorial Foundation
- Astellas Foundation for Research on Metabolic Disorders
- Naito Foundation
- Takeda Science Foundation
- Grants-in-Aid for Scientific Research [23770238, 24590396, 23247035] Funding Source: KAKEN
In most cell types, primary cilia protrude from the cell surface and act as major hubs for cell signaling, cell differentiation, and cell polarity. With the exception of some cells ciliated during cell proliferation, most cells begin to disassemble their primary cilia at cell cycle re-entry. Although the role of primary cilia disassembly on cell cycle progression is still under debate, recent data have emerged to support the idea that primary cilia exert influence on cell cycle progression. In this review, we emphasize a non-mitotic role of Aurora-A not only in the ciliary resorption at cell cycle re-entry but also in continuous suppression of cilia regeneration during cell proliferation. We also summarize recent new findings indicating that forced induction/suppression of primary cilia can affect cell cycle progression, in particular the transition from G0/G1 to S phase. In addition, we speculate how (de)ciliation affects cell cycle progression.
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