AC-magnetic field controlled drug release from magnetoliposomes: design of a method for site-specific chemotherapy

Large unilamellar magnetoliposomes (MLs) with encapsulated doxorubicin (DOX) (anticancer drug) were prepared by reverse-phase evaporation. They were exposed to an alternating magnetic field with a frequency of 3.5 MHz and an induction of 1.5 mT produced in three-turn pancake coil. The results showed that magnetoliposomes could be specifically heated to 42 degreesC (phase transition temperature of a used lipid) in a few minutes and during this, the encapsulated doxorubicin is massively released. (C) 2002 Elsevier Science B.V All rights reserved.