期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 69, 期 16, 页码 2657-2670出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-012-0944-2
关键词
RNA ligase; tRNA; 2 ',3 '-cyclic phosphate; ScTRL1; Rnl1; Rnl2; HSPC117; DDX1; CGI-99; FAM98; ASW; RtcA; RtcB
资金
- Fonds zur Forderung der wissenschaftlichen Forschung [W1207]
- GEN-AU 3 research programme [820982]
- IMBA
- Austrian Science Fund (FWF) [W1207] Funding Source: Austrian Science Fund (FWF)
The discovery of discontiguous tRNA genes triggered studies dissecting the process of tRNA splicing. As a result, we have gained detailed mechanistic knowledge on enzymatic removal of tRNA introns catalyzed by endonuclease and ligase proteins. In addition to the elucidation of tRNA processing, these studies facilitated the discovery of additional functions of RNA ligases such as RNA repair and non-conventional mRNA splicing events. Recently, the identification of a new type of RNA ligases in bacteria, archaea, and humans closed a long-standing gap in the field of tRNA processing. This review summarizes past and recent findings in the field of tRNA splicing with a focus on RNA ligation as it preferentially occurs in archaea and humans. In addition to providing an integrated view of the types and phyletic distribution of RNA ligase proteins known to date, this survey also aims at highlighting known and potential accessory biological functions of RNA ligases.
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