期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 69, 期 18, 页码 3037-3051出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-012-0974-9
关键词
Meiosis; Gametogenesis; Ploidy; Cell cycle; Shugoshin; Monopolin; FEAR
资金
- Biotechnology and Biological Sciences Research Council (BBSRC) [BB/G00353X/1]
- Biotechnology and Biological Sciences Research Council [BB/G00353X/1] Funding Source: researchfish
- BBSRC [BB/G00353X/1] Funding Source: UKRI
Maintenance of ploidy in sexually reproducing organisms requires a specialized form of cell division called meiosis that generates genetically diverse haploid gametes from diploid germ cells. Meiotic cells halve their ploidy by undergoing two rounds of nuclear division (meiosis I and II) after a single round of DNA replication. Research in Saccharomyces cerevisiae (budding yeast) has shown that four major deviations from the mitotic cell cycle during meiosis are essential for halving ploidy. The deviations are (1) formation of a link between homologous chromosomes by crossover, (2) monopolar attachment of sister kinetochores during meiosis I, (3) protection of centromeric cohesion during meiosis I, and (4) suppression of DNA replication following exit from meiosis I. In this review we present the current understanding of the above four processes in budding yeast and examine the possible conservation of molecular mechanisms from yeast to humans.
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