期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 69, 期 17, 页码 2907-2917出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-012-0984-7
关键词
Tuft cells; Brush cells; Intestinal epithelium; Atoh1; Cell differentiation; Dclk1
资金
- Agence Nationale pour la Recherche [ANR-09-BLAN-0368-01]
- Institut National du Cancer [PLBIO09-070]
- Association pour la Recherche contre le Cancer [ARC 5050, SL220110603456]
- Ligue Nationale contre le Cancer (LNCC)
- Agence Nationale de la Recherche (ANR) [ANR-09-BLAN-0368] Funding Source: Agence Nationale de la Recherche (ANR)
The intestinal epithelium, composed of at least seven differentiated cell types, represents an extraordinary model to understand the details of multi-lineage differentiation, a question that is highly relevant in developmental biology as well as for clinical applications. This review focuses on intestinal epithelial tuft cells that have been acknowledged as a separate entity for more than 60 years but whose function remains a mystery. We discuss what is currently known about the molecular basis of tuft cell fate and differentiation and why elucidating tuft cell function has been so difficult. Finally, we summarize the current hypotheses on their potential involvement in diseases of the gastro-intestinal tract.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据