期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 70, 期 12, 页码 2059-2081出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-012-1152-9
关键词
Wound healing; Regeneration; Skin; Wnt; beta-Catenin; Transforming growth factor beta (TGF-beta); Notch; Hedgehog
资金
- Canadian Institutes of Health Research [FRN 15136]
- Ontario Institute for Cancer Research
- Canada Research Chairs Programme
Following a skin injury, the damaged tissue is repaired through the coordinated biological actions that constitute the cutaneous healing response. In mammals, repaired skin is not identical to intact uninjured skin, however, and this disparity may be caused by differences in the mechanisms that regulate postnatal cutaneous wound repair compared to embryonic skin development. Improving our understanding of the molecular pathways that are involved in these processes is essential to generate new therapies for wound healing complications. Here we focus on the roles of several key developmental signaling pathways (Wnt/beta-catenin, TGF-beta, Hedgehog, Notch) in mammalian cutaneous wound repair, and compare this to their function in skin development. We discuss the varying responses to cutaneous injury across the taxa, ranging from complete regeneration to scar tissue formation. Finally, we outline how research into the role of developmental pathways during skin repair has contributed to current wound therapies, and holds potential for the development of more effective treatments.
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