期刊
ARTHRITIS RESEARCH & THERAPY
卷 4, 期 -, 页码 S177-S182出版社
BIOMED CENTRAL LTD
DOI: 10.1186/ar556
关键词
cognate; differentiation; macrophage; signalling; T cells
类别
资金
- Wellcome Trust project grant
- Arthritis and Rheumatism Campaign
Several groups have documented the expression of cytokines in rheumatoid arthritis synovial tissue over the past 15 years or so. These studies have indicated that most cytokines examined are expressed at the mRNA levels at least, and many other cytokines are found in abundance as proteins. Our attention has recently focused on the mechanisms that induce and regulate tumour necrosis factor and IL-10. Other workers and ourselves have found that cell-cell contact is an important signal for the induction of cytokines, and our work has demonstrated that tumour necrosis factor and IL-10 production in rheumatoid arthritis synovial joint cells cultures is dependent on T cell/macrophage interaction. In this chapter, we review recent advances in this area and also highlight areas where new therapeutic intervention opportunities arise.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据