期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 69, 期 14, 页码 2435-2442出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-012-1017-2
关键词
NADPH oxidase; Lymphoma; Melanoma; Hemangioma; Wilms tumor 1; Triphenylmethanes; Fulvenes
资金
- NIAMS [RO1AR 47901, RO1 AR 050727]
- Emory Skin Disease Research Core Center [P30 AR 42687]
NADPH oxidases are a family of oxidases that utilize molecular oxygen to generate hydrogen peroxide and superoxide, thus indicating physiological functions of these highly reactive and short-lived species. The regulation of these NADPH oxidases (nox) enzymes is complex, with many members of this family exhibiting complexity in terms of subunit composition, cellular location, and tissue-specific expression. While the complexity of the nox family (Nox1-5, Duox1, 2) is daunting, the complexity also allows for targeting of NADPH oxidases in disease states. In this review, we discuss which inflammatory and malignant disorders can be targeted by nox inhibitors, as well as clinical experience in the use of such inhibitors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据