期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 70, 期 8, 页码 1425-1437出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-012-1143-x
关键词
Chromatin; DNA motif; Gene expression; Transcription factor; Zygote
资金
- Carlsberg Foundation
- Research Council of Norway
- Norwegian Cancer Society, South East Health Norway
- University of Oslo
The merging of the maternal and paternal genomes into a single pronucleus after fertilization is accompanied by a remarkable reconfiguration of chromatin in the newly formed zygote. The first stages of embryonic chromatin remodeling take place in the absence of ongoing transcription, during a species-specific developmental time-frame. Once post-fertilization chromatin states are organized, zygotic genome activation (ZGA) is initiated, and embryonic transcripts gradually take control of development. We review here transitions in chromatin modifications associated with the onset of ZGA, and the role of transcription factors and DNA motifs in the regulation of ZGA. We propose a model of sequential chromatin remodeling events preceding ZGA, leading to the onset of embryonic transcription.
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