期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 70, 期 17, 页码 3157-3170出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-012-1223-y
关键词
Calorie restriction; Brain ageing; Nutrient sensing; CREB; Stem cell; Neurodegenerative disease
资金
- Catholic University
- Italian Ministry of University and Research (MIUR)
Calorie restriction extends longevity and delays ageing in model organisms and mammals, opposing the onset and progression of an array of age-related diseases. These beneficial effects also extend to the maintenance of brain cognitive functions at later age and to the prevention, at least in rodents, of brain senescence and associated neurodegenerative disorders. In recent years, the molecular mechanisms underlying brain response to calorie restriction have begun to be elucidated, revealing the unanticipated role of a number of key nutrient sensors and nutrient-triggered signaling cascades in the translation of metabolic cues into cellular and molecular events that ultimately lead to increased cell resistance to stress, enhanced synaptic plasticity, and improved cognitive performance. Of note, the brain's role in CR also includes the activation of nutrient-sensitive hypothalamic circuitries and the implementation of neuroendocrine responses that impact the entire organism. The present review addresses emerging molecular themes in brain response to dietary restriction, and the implications of this knowledge for the understanding and the prevention of brain disorders associated with ageing and metabolic disease.
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