期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 69, 期 14, 页码 2365-2371出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-012-1012-7
关键词
Fibrosis; NADPH oxidase; Oxidative stress
资金
- U.S. National Institutes of Health [R01 HL067967, R01 HL094230, R01 HL086836]
Oxidative stress has been associated with a number of human fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). Oxidative stress is most often defined as an imbalance between the generation of reactive oxygen species (ROS) in excess of the capacity of cells/tissues to detoxify or scavenge them. Additionally, the regulated production of ROS participates in cellular signaling. Therapeutic strategies to treat IPF have, thus far, focused on augmenting anti-oxidant capacity. Recent studies have demonstrated a critical role for ROS-generating enzymatic systems, specifically, NADPH oxidase (NOX) family oxidoreductases in fibrotic processes. In this review, we examine the evidence for NOX isoforms in the generation and perpetuation of fibrosis, and the potential to target this gene family for the treatment of IPF and related fibrotic disorders.
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